DERIVES DE L'ACIDE MONOCHLORACETAMIDO-7 DESACETOXY-3 CEPHALOSPORANIQUE LEUR PREPARATION ET LEUR EMPLOI

摘要

1454588 7-Chloroacetamido-3-desacetoxycephalosporanic acid derivatives RHONEPOULENC SA 5 Sept 1974 [6 Sept 1973] 38882/74 Heading C2C The invention comprises compounds of the formula wherein R is an ester radical, e.g. C 1 -C 4 alkyl or benzyl which may be substituted by C 1 -C 4 alkoxy. They may be obtained by (a) heating a compound of the formula in an anhydrous acid medium, or (b) treating a compound of the formula with Zn in acetic acid. 7 - Amino - 3 - desacetoxy - cephalosporanic acid is obtained by hydrolysis or hydrogenolysis of a compound of Formula I to give a compound of the formula and treating this compound with thiourea in aqueous solution.