| 摘要 |
1509853 4 - Amino - 3 - hydroxy - 6 - nitrobenzoylpyran derivatives BEECHAM GROUP Ltd 15 Dec 1976 [27 Jan 1976] 02994/76 Heading C2C Novel compounds of Formula II and salts thereof wherein A 1 is a hydrogen, fluorine or chlorine atom or a hydroxy, methoxy or methyl group; A 2 is a hydrogen atom or a C 1-4 alkyl group; A 3 is a hydrogen atom or a C 1-4 alkyl group; A 4 is a hydrogen atom or a C 1-4 alkyl group; A 5 is a group -X-Y wherein X is an alkylene group of 2 to 6 carbon atoms and Y is a halogen atom or a -OZ group wherein Z is a C 1-7 hydrocarbon, methanesulphonyl, toluene-p-sulphonyl or phenylsulphonyl; and A 6 is a hydrogen atom or a -COA 7 group wherein A 7 is C 1-8 hydrocarbon group optionally substituted by halogen or hydroxy are prepared by reaction of a compound HNA 4 A 5 with a suitable 3, 4 epoxybenzopyran. Pharmaceutical compositions in conventional forms for oral or parenteral administration having antihypertensive activity comprise an above novel compound and optionally a further #-blocking sgent and/or diuretic. |
