FLERSTEGSFORFARANDE FOR FRAMSTELLNING AV 2-AMINOETYLPYRROLIDIN MED N-BENSYL-2-NITROMETYLEN-PYRROLIDIN

摘要

1481251 2 - Aminomethylpyrrolidine SOC D'ETUDES SCIENTIFIQUES ET INDUSTTRIELLES DE L'ILE-DE-FRANCE 24 Feb 1975 [4 March 1974] 7645/75 Heading C2C 2 - Aminomethylpyrrolidine and its acid addition salts are prepared by reacting 2-pyrrolidone in a basic medium in a solvent with a reactive benzyl compound of formula wherein X is a reactive atom or group (e.g. a halogen atom or a tosyl group), to produce N- benzyl-2-pyrrolidone, treating the latter with a di(C 1-3 alkyl)sulphate and an alkali metal alcoholate, followed by nitromethane, to produce N-benzyl-2-nitromethylene-pyrrolidine and then (a) reducing the latter to 2-aminomethylpyrrolidine by hydrogen in the presence of a catalyst either directly or via the intermediate N-benzyl-2-aminomethyl-pyrrolidine or (b) reducing to N-benzyl-2-aminomethyl-pyrrolidine by a metal/acid system and then to 2-aminomethyl-pyrrolidine by hydrogen in the presence of a catalyst, the 2-aminomethyl-pyrrolidine being optionally converted to an acid-addition salt by treatment with an acid.