| 发明名称 |
Methylation of de-A steroids |
| 摘要 |
Treatment of de-A steroids with a methylation agent at extremely low temperatures, i.e., below -50 DEG C. produces corresponding 10 beta -methyl- DELTA 9(11)-deA steroids with a high 10 beta to 10 alpha isomer ratio. A number of the product 10 beta -methyl- DELTA 9(11)-deA steroids are novel compounds. They are useful as intermediates in the synthesis of known medicinally valuable steroids.
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| 申请公布号 |
US4087436(A) |
申请公布日期 |
1978.05.02 |
| 申请号 |
US19750589650 |
申请日期 |
1975.06.23 |
| 申请人 |
HOFFMANN-LA ROCHE, INC. |
发明人 |
BUCHSCHACHER, PAUL;FURST, ANDOR;LABLER, LUDWIG;MEIER, WERNER;SCOTT, JOHN WILLIAM |
| 分类号 |
C07C49/417;C07D261/08;C07J1/00;C07J7/00;C07J17/00;C07J43/00;(IPC1-7):C07D261/06;C07D317/08;C07C49/54;C07C49/60 |
主分类号 |
C07C49/417 |
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