发明名称 |
PREPARATION OF QUINOXALINE-1,4-DIOXIDES AND INTERMEDIATES THEREFOR |
摘要 |
The carbazates of formula I are obtained by reacting the quinoxaline N<1>,N<4>-dioxides carrying in position 2 a chloromethyl or bromomethyl group with one to two equivalents of an alkali metal carbonate and one to two equivalents of a hydrazine of formula R''NH-NH-COOCH3 at a temperature of between 75 and 85 DEG C and in an inert solvent. This hydrazine is prepared by reaction of methyl carbazate with a corresponding acid anhydride or sulphonyl halide which introduces the radical R''. The meaning of the symbols is explained in Claim 1. The compounds of formula I are strong antibacterial agents. <IMAGE> |
申请公布号 |
ZA7702979(B) |
申请公布日期 |
1978.04.26 |
申请号 |
ZA19770002979 |
申请日期 |
1977.05.18 |
申请人 |
PFIZER INC |
发明人 |
CZUBA L |
分类号 |
C07C311/00;A61K31/495;A61K31/498;A61P17/00;A61P31/04;A61P33/02;B01J19/00;C07C67/00;C07C301/00;C07C311/49;C07D241/44;C07D241/52 |
主分类号 |
C07C311/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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