| 摘要 |
A nucleotide derivative represented by the general formula: <IMAGE> wherein R represents an acyl group having 14 - 22 carbon atoms and having an aliphatic acyl moiety; X represents a hydrogen atom, a halogen atom, an alkyl group having 1 - 4 carbon atoms, or a trifluoromethyl group; and at least one, but not all, of Y1, Y2, and Y3 represents a phosphate, a pyrophosphate, a triphosphate, or a salt thereof, the balance of Y1, Y2 and Y3 representing a hydroxyl group; or in case of ribosyl, Y1 and Y3, or Y2 and Y3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt thereof and the remaining group of Y1, Y2 or Y3 represents a hydroxyl group; or in case of arabinosyl, Y1 and Y2, or Y2 and Y3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt therof and the remaining group of Y1, Y2 or Y3 represents a hydroxyl group. The nontoxic salts of these phosphates are useful as an antileukemialagent for mice which is soluble in water and has high stability.
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