Method of preparation of insoluble biologically active compounds

摘要

The invention relates to biologically active insoluble compounds on a carrier containing in its side chains a p-phenylene-diamine skeleton, where a polymer of the general formula I I where R1 is a polymer residue, R2 is a lower alkyl group, x = 1-4, is oxidized in the presence of a soluble biologically active compound containing a primary amino group, such as e.g. enzymes, coenzymes, inhibitors of enzymes, hormones, or antigens. The oxidation is carried out by using an oxidation agent which does not disturb the biologically active compounds present in the mixture.