PROCEDE DE PREPARATION DE COMPOSES D'ACIDE 3-CEPHEM-4-CARBOXYLIQUE,3,7-DISUBSTITUE NOUVEAUX PRODUITS AINSI OBTENUS ET LEUR UTILISATION POUR COMBATTRE LES MALADIES PROVOQUEES PAR DES BACTERIES PATHOGENES

摘要

3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: in which R1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R2 is hydrogen or lower alkyl; R3 is carboxy or protected carboxy; R4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.