| 摘要 |
NEW MATERIAL:beta-D-glucan NMF. Appearance, almost white powder; elemental analysis, C 41.0-44.2%, H 6.9-7.3%, N below the detectable limit; molecular weight, 500,000-1,500,000 (gel-filtration); melting point, about 230 deg.C (decomposition); specific rotation, [alpha]D<20>=+5-+10 (C=0.1, H2O); solubility, easily soluble in alkali, water and dimethyl sulfoxide, slightly soluble in acid, insoluble in organic solvent; color reactions, positive to Molish reaction, anthrone-sulfuric acid reaction and phenol-sulfuric acid reaction, negative to ninhydrin reaction; nature, slightly acidic or neutral (6-7 pH) as 1% aqueous solution. USE:Carcinostatic agent which can be applied by peroral adminstration as well as peritoneal infusion, injection to the tumor and intravenous injection. PREPARATION:The mat-like mycelia of Grifola frondosa (an inedible part of the fungus) is extracted with hot water, and the extraction residue is subjected successively to the low-temperature alkali extraction and the high-temperature alkali extraction. Each extract solution is dialyzed, and the remained liquid is concentrated, and precipitated and fractionated with ethyl alcohol to obtain the objective compound. |
