SYNTHETICALLY MODIFIED TRYPSIN INHIBITORS AND PROCESS FOR PREPARING THEM

摘要

Modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by -(R)(R)XW groups, WHEREIN R is prolyl or -NH-CH-CO-, ¦ Y X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is -OH, -NH2, -NHC2H5, -OCH3, or -OC2H5. Method for making trypsin-callicrein inhibitor so modified by amidation.