发明名称 |
PROCESS FOR THE OBTAINMENT OF 2,4,5-TRIMETHYL-THIENO-/3,2-F/ MORPHANE |
摘要 |
<p>1513980 Tetrahydropyridine derivatives LABORATORIOS MADE SA 25 Aug 1976 [19 Sept 1975] 35397/76 Heading C2C The novel compound of Formula I and salts thereof are prepared by reaction of a compound of Formula II with methyl iodide followed by reduction with NaBH 4 . II may be prepared by hydrazine reduction of a compound of Formula III prepared by reaction of lithiophene with 2- cyano-4,5-dimethyl pyridine obtained by reaction of an alkali metal cyanide with the reaction product of 2,3-dimethylpyridine N-oxide and an alkylating agent. Compounds of Formula I above are cyclized with strong acid to give a compound of Formula IV Pharmaceutical compositions in conventional forms having analgesic activity comprise a compound of Formula I above or a salt thereof or a compound of Formula IV above and a carrier or diluent.</p> |
申请公布号 |
PT65547(B) |
申请公布日期 |
1978.03.24 |
申请号 |
PT19760065547 |
申请日期 |
1976.09.02 |
申请人 |
LABORATORIOS MADE, S.A. |
发明人 |
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分类号 |
C07D495/08;A61K31/38;A61K31/435;A61K31/44;A61K31/4433;A61K31/4436;A61P25/20;C07D213/84;C07D221/02;C07D333/00;C07D409/06;C07D409/12 |
主分类号 |
C07D495/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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