摘要 |
<p>1503614 Process for preparing 1-(tetrahydro- 2-furanyl)-5-fluorouracil UNIVERSITY OF UTAH 14 April 1975 [6 May 1974] 15282/75 Heading C2C [Also in Division C3] A novel process for preparing 1-(tetrahydro-2- furanyl)-5-fluorouracil comprises reacting bistrimethylsilyl-5-fluorouracil with 2-halotetrahydrofuran, and, if necessary, removing the trimethyl silyl protecting group. 1 - (Tetrahydro - 2 - furanyl) - 5 - fluorouracil is an antimetabolite active against cancer of the breast and of the gastro-intestinal tract.</p> |