| 摘要 |
Described are 3-oxo-7 alpha -halogeno-17 alpha -1,4-pregnadiene-21,17 beta -carbolactones and compounds related thereto, i.e. 2',3' alpha -tetrahydrofuran-2'-spiro-17(7 alpha -halogeno-1,4-androstadiene-3-ones) and (17R)-spiro-[7 alpha -halogeno-1,4-androstadiene-17,1'-cyclobutane]-3,2'-diones, all of which are valuable as aldosterone antagonists. Also described are the corresponding 7 beta -hydroxy derivatives useful as intermediates.
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