发明名称 |
NYTT SESKVIHYDRAT AV NAFTYRIDINDERIVAT OCH FOERFARANDE FOER DES FRAMSTAELLNING |
摘要 |
Novel 1-ethyl-6-fluoro-1,4-dihyono-4-oxo -7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid.sesquihydrate (ATT-2266.sesquihydrate). The aforesaid compound can be prepared by heating 1-ethyl-6-fluoro-1,4-dihydro-4-oxo -7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid at a temperature above about 60 DEG C. in the presence of water in an amount sufficient to form the sesquihydrate. This sesquihydrate is much more stable than the anhydrate and the trihydrate and is superior to the anhydrate in the rate of dissolution and transference into the body through the intestines. Thus, it is especially useful as a pharmaceutical compound. |
申请公布号 |
FI820466(L) |
申请公布日期 |
1982.08.14 |
申请号 |
FI19820000466 |
申请日期 |
1982.02.12 |
申请人 |
DAINIPPON PHARMACEUTICAL CO LTD |
发明人 |
ICHIHASHI HITOSHI;TANAKA TERUKAZU;IMASATO YU |
分类号 |
C07D487/04;A61K31/495;A61P31/04;C07D213/73;C07D213/74;C07D213/75;C07D213/77;C07D471/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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