2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE AND SALTS THEREOF,A PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

摘要

Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I I which have valuable pharmacological properties are provided. In said Formula I the acyl group -CO-R3 represents a benzoyl group or a phenyl alkanoyl group which may be unsubstituted or mono- or di-substituted in the phenyl ring. The substituent R1 in said compounds indicates lower alkyl, lower alkenyl, or cyclopropyl methyl, and the substituent R2 indicates hydrogen, lower alkyl, or lower alkenyl, while the substituent R6 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoro methyl, cyano, amino, mono- or di-lower alkyl amino, lower mono-alkanoyl amino, lower N-alkyl-N-alkanoyl amino, or lower alkanoyloxy, and the substituent R7 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, whereby R6 and R7, when attached to adjacent carbon atoms, may form together the methylene dioxy or the ethylene dioxy group. The substituents R8 and R9 designate the same substituents as indicated for the substituents R6 and R7. The compounds of Formula I have a surprising analgesic activity.