| 摘要 |
<p>1451721 11-Oxygenated steroids ROUSSEL UCLAF 4 Jan 1974 [5 Jan 1973] 00354/74 Heading C2U The invention comprises compounds I infra, their preparation from compounds II-VII and their conversion into compounds VIII-X R = Me, Et, Pr ; R<SP>1</SP> = C 1-3 alkyl ; R<SP>2</SP>=oxo, ketal or (H, #-OR<SP>3</SP>); R<SP>3</SP>=H or C 1-12 carboxylic acyl; R<SP>4</SP>=ketal or (H, #-OR<SP>3</SP>); R<SP>5</SP>=oxo or (H, #- OR<SP>3</SP>); X=H or OH; Y=C 1-4 alkyl or haloalkyl ; W=H or OCOY; Z = H or #<SP>4</SP>-unsaturation. Reagents: II # III epoxidizing agent; III # IV Lewis acid; IV # I(X=H), e.g. alumina or alkali metal base; IV # V epoxidizing agent; V # I(X=OH) strong base; IV # VI, e.g. alkali metal alcoholate; VI # VII epoxidizing agent; VII # I(X=OH) alkaline agent; I(R<SP>2</SP>=oxo) # I(R<SP>2</SP>=ketal), e.g. ethylene glycol or specified dioxolanes I(R<SP>2</SP> = R<SP>4</SP>) # VIII RMgHal, then functional deriv. of YCO 2 H; VIII (W=H) # IX (Z = H) acid then base; VIII (W = OCOY) # IX (Z = #<SP>4</SP>) acid; I(X =α-H; R<SP>2</SP>=R<SP>4</SP>) # X RMgHal; X # IX (10α-R; Z=a-H) acid.</p> |
