发明名称 |
6-(Bromomethyl)-2,4-diaminopteridine hydrobromide |
摘要 |
A pteridine compound having the formula of 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. 2,4-diamino-6-pteridine-methanol.HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form 6-(bromomethyl)-2,4-diaminopteridine hydrobromide. The bromine atom in the molecule can then be replaced with the functional group, N-[4-(methylamino)-benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin.
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申请公布号 |
US4077957(A) |
申请公布日期 |
1978.03.07 |
申请号 |
US19770786414 |
申请日期 |
1977.04.11 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE |
发明人 |
PIPER, JAMES R.;MONTGOMERY, JOHN A. |
分类号 |
C07D475/08;(IPC1-7):C07D475/08 |
主分类号 |
C07D475/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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