| 摘要 |
Anti-inflammatory D-homosteroids of the formula <IMAGE> in which the dotted 1,2 bond denotes an optional C-C bond; R<6> denotes hydrogen, fluorine, chlorine or methyl; R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha . |
