FREMGANGSMAATE VED FREMSTILLING AV ET BLODKOAGULERINGSFREMMENDE PREPARAT

摘要

In a method of producing a blood-coagulation-promoting preparation from human blood plasma, which preparation contains a new blood-coagulating substance called "FEIBA", human plasma with citrate ions is treated with water-insoluble inorganic coagulation-physiologically-surface-active substances in the absence of free calcium ions, thus generating "FEIBA", the water-insoluble substances are separated, the supernatant is treated with basic ion exchangers, wherein "FEIBA" and the coagulation factors II-VII-IX-X adhere to the ion exchangers, and "FEIBA" and the factors II-VII-IX-X are eluted and concentrated.