发明名称 |
Conversion of acid S, produced by the organism {i Polyangium cellulosum {b var. {i fulvum {b into acid F |
摘要 |
A process for the conversion of the major antifungal antibiotic, acid S (ATCC NO. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.
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申请公布号 |
US4076940(A) |
申请公布日期 |
1978.02.28 |
申请号 |
US19770794180 |
申请日期 |
1977.05.05 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
CONNOR, DAVID T.;VON STRANDTMANN, MAXIMILIAN |
分类号 |
C07D309/18;(IPC1-7):C09B23/00 |
主分类号 |
C07D309/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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