3-(HYDROXYMETHYL) DERIVATIVES OF POLYCYCLIC GAMMA-PYRONES AND PROCESS FOR THEIR PREPARATION

摘要

1416670 Polycyclicγ-pyrone derivatives WARNER-LAMBERT CO 12 Aug 1974 [13 Aug 1973] 35409/74 Heading C2C The invention comprises compounds of the formula wherein the Z ring is of the following structure They may be obtained by reacting a compound of the formula with HCHO under basic conditions to give a compound of the formula followed by thermal treatment to eliminate methyl sulphonic acid. Pharmaceutical compositions useful in providing relief of gastric hyperacidity and symptomatic relief of allergic conditions such as asthma and hay fever, comprise compounds of Formula I in association with solid or liquid carriers or diluents and may be administered orally, parenterally, by injection or by inhalation.