PROCESS FOR ISOLATION OF DIPEPTIDE ESTERS

摘要

1435481 Isolation of L-aspartyl dipeptide esters G D SEARLE & CO 4 March 1974 [5 March 1973] 9603/74 Heading C3H A process for isolating a dipeptide ester of general formula wherein X is a phenyl or p-hydroxphenyl radical, R is an alkyl radical of 1-7 carbon atoms and the stereochemical configuration is L-L, from an impure mixture containing said dipeptide ester which comprises partitioning said impure mixture between water and a waterimmiscible alcohol; between water and a mixture of a water-miscible alcohol and a water immiscible alcohol; or between water and a water-miscible alcohol, wherein the solubility of the alcohol in water is suppressed by the addition of inorganic salts to the aqueous layer and isolating the dipeptide ester from the alcohol layer. The isolation of h-α-aspartyl-hphenylalanine methyl ester and L-α-aspartyl-L- tyrosine methyl ester is described.