| 摘要 |
The invention relates to novel amidino-hydrazone derivatives of the general formula: <IMAGE> I in which the dotted lines mean one extra bond starting from the (guanidine-) carbon atom to one of the adjacent nitrogen atoms, and A stands for methylene, ethylene, propylene or butylene, which groups may optionally be substituted with alkyl (1-4 C), R stands for hydroxy, alkyl (1-4 C), alkylthio or alkoxy (1-4 C), halogen, trifluoromethyl, nitro, amino, hydroxymethyl, acyloxy or an alkylenedioxy group, N IS THE NUMBER 0, 1, 2, 3 OR 4, R1, R4 and R5 represent hydrogen or alkyl (1-4 C), with the proviso that one of them is absent in view of the presence of the double bond, R2 and R3 stand for hydrogen, alkyl (1-4 C), aralkyl, aryl, hydroxy or amino, with the proviso that R2 + R3 together may also represent a saturated or unsaturated alkylene group with 2 or 3 carbon atoms, or R3 + R4 together with the nitrogen atom may also stand for a heterocyclic five- or six-membered ring, AS WELL AS THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, HAVING VALUABLE, ANTIHYPERTENSIVE AND ANTITHROMBOSIS ACTIVITIES.
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