PROCESS FOR PRODUCING OPTICALLY ACTIVE N-CYCLOPROPYLMETHYL-3-HYDROXY-9-AZA-MORFINANE AND 3-HYDROXY-9-AZA-MORFINANE

摘要

dl-N-Cyclopropylmethyl-3-hydroxy-9-azamorphinan is a compound known to possess analgesic activity that is about twice as potent as pentazocine. Resolution of the compound into its levorotatory and dextrorotatory isomers and subsequent animal testing revealed that l-N-cyclopropylmethyl-3-hydroxy-9-azamorphinan was much more potent than the dl-mixture.