| 摘要 |
NEW MATERIAL:A compound expressed by formula I [R<1> is H, (substituted) alkenyl, cycloalkenyl or alkynyl; R<2> is H, metal, ester residue, salt-forming cation or anion electric charge when COO<-> forms an intramolecular or extramolecular salt with a cation pair; n is 0 or 1; A is (substituted) benzothiazolylthiomethyl, etc.] and salt thereof. EXAMPLE:Sodium 7-[2-(2-aminothiaozol-4-yl)-2-(2-propenyloxyimino)acetamido]- 3-(benzothiazolylthio)methyl-3-cephem-4-carboxylate expressed by formula IV. USE:An antimicrobial agent against Gram-positive and Gram-negative bacteria, particularly Gram-positive bacteria. PREPARATION:A compound expressed by formula III (Tr is trityl) is reacted with a benzothiazole compound expressed by formula IV-VII (R<13> is 1-6C alkyl, etc.) to give a cephalosporin derivative expressed by formula VIII, which is subjected to reduction, deprotection reaction, etc., as necessary.
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