发明名称 |
Preparation of leurosidine and novel leurosidine 4{40 -ethers and esters |
摘要 |
Vincaleukoblastine (VLB, vinblastine) is converted to leurosidine, its 4' epimer, by reaction with thionyl chloride to form a bis-sulfite ester followed by treatment of the bis-sulfite ester with silver perchlorate. The bis-sulfite ester is covertible to novel 4' ethers by treatment with a lower alkanol or 4' esters of leurosidine perchlorate with acetic anhydride.
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申请公布号 |
US4075214(A) |
申请公布日期 |
1978.02.21 |
申请号 |
US19760687274 |
申请日期 |
1976.05.17 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
KATNER, ALLEN S.;GUTOWSKI, GERALD E.;MILLER, JEAN C. |
分类号 |
C07D519/04;(IPC1-7):C07D471/18 |
主分类号 |
C07D519/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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