| 摘要 |
In a process for preparing new benzalazinium-methane-sulphonates of formula (I): (where R1 is H, Cl, Br, I, F, NO2, CN, CF3, COOH, OH, amino, lower alkoxy, lower carbalkoxy or lower prim. or sec. amino; and R2 is H, lower alkyl, lower alkenyl, cycloalkyl or (lower alkoxy)-(lower alkyl)), an azine of formula (II) is reacted with a cpd. of the formula HO-CH2-SO3M (III) (where M is an alkali metal).(I) have low toxicity coupled with anthelmintic activity, partic. against trematodes, esp. schistosomes and liver flukes. A specific cpd. (Ie is that in which R1 is Cl and R2 is H. In an example, this is prepd. by reacting (II); R1=Cl, R2=H) in water with (III); M=Na) at 85 degrees C.
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