TISSUE-DERIVED TUMOR GROWTH INHIBITORS, METHODS OF PREPARATION AND USES THEREOF

摘要

2056981 9014360 PCTABS00002 This invention provides a protein having tumor growth inhibitory activity comprising the 112 amino acids (shown in Figure 29) beginning with alanine at position 1 and ending with serine at position 112. The protein may also comprise the 412 amino acids (shown in Figure 41) beginning with methionine at nucleotide position 263 and ending with serine at nucleotide position 1496. Thus, this 412 amino acid sequence contains the complete precursor sequence of the protein having tumor growth inhibitory activity as well as the complete sequence of the mature protein (shown in Figure 29) beginning with alanine at position 1 and ending with serine at position 112. Finally, the invention provides a protein comprising the 411 amino acids (shown in Figure 41) beginning with lysine at nucleotide position 266 and ending with serine at nucleotide position 1496.