ANTRACYKLINETRAR OG FREMGANGSMADE FOR DERES FREMSTILLING

摘要

Novel antitumor antibiotics, which are daunomycin analogues of the formula: I wherein R1 is hydrogen or a C1-C4 lower alkyl, R2 is a C1-C4 lower alkyl, a C3-C6 cycloalkyl, phenyl, lower alkyl phenyl, lower alkoxy phenyl or halophenyl, and R3 is hydrogen or trifluoroacetyl are prepared by condensing 2,3,6-trideoxy-3-trifluoroacetamido-4-0-trifluoroacetyl- alpha -L-lyxopyranosyl chloride with novel aglycones of the formula: II, which are in turn prepared by a novel method from 14-bromodaunomycinone through a series of novel intermediates.