| 摘要 |
Cpds. of formula (I): where R = 1-3C alkyl, 1-3C haloalkyl or 1-3C hydroxyalkyl; R1 = -NR3R4 or -N=CR5-X; R2 = H, -CN, -COOH or -CONHR6; R3, R4 = same or different H, 1-3C alkyl, 1-4C alkanoyl or -SO2N(CH3)2; R5 = H or 1-3C alkyl; X = -OR7, phenyl, -CH=CH-CH3, -CH=CH-C6H5, -CCl3, 2-furyl, 3-pyridyl, 3,4-methylenedioxyphenyl, -NH-NH-1-4C alkyl or -NR8R9; R6 = H or 1-4C alkanoyl; R7 = 1-8C alkyl, 2-5C alkenyl or 1-3C haloalkyl; R8, R9 = same or different 1-3C alkyl. Specif. claimed are (I) where R2 = CN and (a) R=CH3 and R1 = -NH2, -N=CH-OCH3 and -N=CH-OC4H9 and (B) R = C2H5 and R1 = -NH2. (I) are useful as antibacterials, antifungals and antiprotozoals active against Escherichia coli, Pasteurella multocida, Salmonella Typhimurium, Treponema hyodysentereae and coccidiosis etc. |
