| 摘要 |
PIPERAZINE DERIVATIVES Compounds are disclosed of formula (I) wherein R1 represents -COR4, -C02R4, -COCO2R4 or -CONR4Rs (where R4 and RS may be the same or different and represent a hydrogen atom or a Cl_3slkyl group); R2 represents a hydrogen atom or a hydroxy or oxo group, with the proviso that when R1 is -COR4, -CO2R4 or -COCO2R4, R2 is not a hydrogen atom; R3 represents a hydrogen atom or a hydroxy group; X represents a direct bond, -CH2- or -CH20-; Ar represents a substituted phenyl moiety; and physiologically acceptable salts thereof. The compounds are indicated as useful in the treatment of pain. Processes for their preparation and pharmsceutical compositions containing them are also disclosed.
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