Intermediates and process for the preparation of an antiviral agent

摘要

(1R,trans) Diprotected 3-methylene-1,2-cyclopropanedimethanol is oxidized to an optically active diol intermediate which is then cyclized to an orthoester intermediate, and then converted to the (2S-trans)diprotected 2,3-bis(hydroxymethyl)cyclobutanone. This cyclobutanone is useful as an intermediate in the preparation of the antiviral agent Ä1R-(1 alpha ,2 beta ,3 alpha )Ü-2-amino-9-Ä2,3-bis(hydroxymethyl)cyclobutylÜ-1,9-dihydro-6H-purin-6 -one.