PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS

摘要

The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a living animal body in need thereof a therapeutically effective amount of a compound having formula (I) or a pharmaceutically acceptable salt thereof wherein R?2, R3, R4 and R5¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R?3 and R4 or R4 and R5¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?2, R3, R4 and R5¿ is as defined above; Y is -CO-, -CS-, -SO¿2?-, or -C(=N-R?8¿)-, wherein R8 is hydrogen, alkyl, or cyano; X is -NH-, -CH¿2?-NH-, -SO2-NH-, or -CH2-; Z is -NR?6¿-, -O-, -CH=CH-, -N=CH-, -CH=N-, or -NR6-CH2-, wherein R6 is hydrogen, or alkyl; R?11, R12, R13, R14 and R15¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R?11 and R12, R12 and R13, R13 and R14 or R14 and R15¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?11, R12, R13, R14 and R15¿ is as defined above.