| 摘要 |
PURPOSE: To obtain a composition for oral cavity which is composed of a water- insoluble noncationic antimicrobial, a specific antimicrobial increasing agent and a vehicle, possesses enhanced delivery and retention of antimicrobials and is useful for lowering generation of gingivitis. CONSTITUTION: This composition comprises (A) a substantially water-insoluble noncationic antimicrobial, e.g. halogenized diphenyl ether (particularly triclosan) and halogenized salicylanilide, (B) an antimicrobial increasing agent for enhancing delivery of the antimicrobial to oral cavity surface and its retention there, for example, a polymer having delivery-increasing groups (e.g. oxygen, phosphonic acid and carboxylic acid) and/or organic retentive increasing groups [e.g. O(X)n -R (X is 0, N and S; R is an alkyl, an aryl and an acyl; (n) is O and 1)], e.g. a poly (β-styrene-phosphonic acid, and (C) a vehicle useful for dissolving the antimicrobial in an amount showing dental calculus-resistant effect into saliva. The composition contains the component B in the range of 0.005-4wt.%.
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