CLAVULANIC ACID DIAMINE SALTS, METHOD OF THEIR SYNTHESIS (VARIANTS), METHOD OF SYNTHESIS OF CLAVULANIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF PURIFICATION OF CLAVULANIC ACID OF ITS SALT

摘要

FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to new clavulanic acid diamine salts of the formulas (IIa, IIb) where R1 and R2 each means (C1-C4)-alkyl group or they bound each with other to form piperidino-group or morpholino-group; R3 and R4 each means (C1-C4)-alkyl group or they bound each with other to form piperidino-group; X means hydrogen atom or hydroxy-group; m and n each independently = 0-5. Compounds of the formula (IIa, IIb) are synthesized by interaction of clavulanic acid with diamine of the formula (III) in an organic solvent. Invention proposes a method of purification of clavulanic acid also. EFFECT: improved and simplified method of synthesis. 12 cl, 2 tbl, 8 ex