发明名称 |
SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS |
摘要 |
Quinoxaline compounds are described as well as method for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the chemokine binds to an IL-8a (CXCR1) or b (CXCR2) receptor such as, a chemokine-mediated disease selected from psoriasis, or atopic dermatitis, disease associated with pathological angiogenesis (i.e. cancer), asthma, chronic obstructive pulmonary disease, adult respiratory distress syndrome, arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, gastric ulcer, septic shock, endotoxic shock, gram-negative sepsis, toxic shock syndrome, stroke, cardiac and renal reperfusion injury, glomerulo-nephritis, or thrombosis, Alzheimer's disease, graft versus host reaction, or allograft rejections. |
申请公布号 |
WO9942461(A1) |
申请公布日期 |
1999.08.26 |
申请号 |
WO1998US26707 |
申请日期 |
1998.12.15 |
申请人 |
WARNER-LAMBERT COMPANY;CONNOR, DAVID, THOMAS;LI, JIE, JACK;LOW, JOSEPH, EDWIN;MILLER, STEVEN, ROBERT;ROTH, BRUCE, DAVID;TRIVEDI, BHARAT, KALIDAS |
发明人 |
CONNOR, DAVID, THOMAS;LI, JIE, JACK;LOW, JOSEPH, EDWIN;MILLER, STEVEN, ROBERT;ROTH, BRUCE, DAVID;TRIVEDI, BHARAT, KALIDAS |
分类号 |
C07D241/44;C07D401/04;C07D401/14;C07D403/04;C07D405/04;C07D409/04;C07D409/14;C07D413/04;C07D413/14;C07D417/04;C07D453/02;C07D521/00 |
主分类号 |
C07D241/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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