ANDROGEN RECEPTOR MODULATOR FUSED QUINOLINE AND INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Cpds. of formula e.g. (I), (II), (VII) and (XII) are new: (I) = (A; X1 = R1); (II) = (A; X1 = a gp. of formula (i)); (VII) = (C; either K = CR3 and L = CH or K = CHR3 and L = CH2); (XII) = (C; K = CR3R21 and L = C=X); R1 = heteroaryl opt. substd. by 1-4C alkyl, F, Cl, Br, NO2, CO2H, CO2R2, CHO, CN, CF3, CH2OH or COMe, and is attached through C or N atom; R2 = H, 1-4C alkyl or perfluoroalkyl, aryl, heteroaryl or opt. substd. allyl, arylmethyl, alkynyl or alkenyl; R3 = H, 1-4C alkyl or perfluoroalkyl, hydroxymethyl, aryl, heteroaryl or opt. substd. allyl, arylmethyl, alkynyl or alkenyl; R4-R6, R11-R15 = H, F, Cl, Br, I, NO2, CO2H, CO2R2, CN, CF3, CH2OH, 1-4C alkyl or perfluoroalkyl, OR2, SR2, S(O)R2, SO2R2, SO3H, S(NR2R7)R2, S(O)(NR2R7)R2, NR2R7, aryl, heteroaryl or opt. substd. allyl, arylmethyl, alkynyl or alkenyl; R7 = H, 1-4C alkyl or perfluoroalkyl, aryl, heteroaryl, opt. substd. allyl or arylmethyl, OR8 or NHR8; R8 = H, 1-6C alkyl or perfluoroalkyl, aryl, heteroaryl, opt. substd. allyl or arylmethyl, SO2R2 or S(O)R2; R9, R10 = H, 1-6C alkyl or perfluoroalkyl, aryl, heteroaryl or opt. substd. allyl, arylmethyl, alkynyl or alkenyl; or R9 + R10 = 3-7 membered ring opt. substd. by H, F, OR2 or NR2R7; X = CH2, O, S or NR7; R20 = 1-6C alkyl or opt. substd. allyl, arylmethyl, alkenyl, aryl or heteroaryl; R21 = H, 1-4C alkyl or opt. substd. allyl, arylmethyl, aryl or heteroaryl; with provisos.