| 摘要 |
Indole derivatives of formula (I) are new. R' = H, halo, OH, Q, QO, NR3R4 or NHCOQ; V = O, NH or NQ; T = 1-4C alkylene (optionally substituted by halo or Q); W = 1-2C alkylene (optionally substituted by halo or Q); J = X-C(Y)(S') or, when, T and W are both methylene, a group of formula -(CH2)nCH2C(CH2NR3R4)=C(halo)- (i), -(CH2)nC(halo)=C(CH2NR3R4)(CH2)m- (ii) or -C(halo)=CHCH(CH2NR3R4)(CH2)n- (iii); n, m = 1 or 2; X = O, S or a bond; Y = halo, Q or H; S' = CHO or C(Z)(R2)(M); M = H, CH2OR5, CH2NR3R4 or NR3R4; R2 = H or halo; Z = H or OR6; R3, R4 = H, Q, halo-Q, 1-4C alkanoyl or halo(1-4C alkanoyl); or NR3R4 = a 5-6 membered ring; R5, R6 = H, Q, halo-Q, 1-4C alkanoyl or halo(1-4C alkanoyl); or R5+R6 = a divalent group of formula CR7R8; R7, R8 = H, Q or halo-Q; or CR7R8 = a 5-6 membered ring; Q = 1-4C alkyl; provided that at least one of Y, S', T and W = halo or a halo-substituted group, or T and W are both methylene. |
