发明名称 |
METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OFANEMIA |
摘要 |
Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount o f recombinant human erythropoietin to obtain a comparable target hematocrit an d treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and trea t anemia. Also disclosed are new hyperglycosylated erythopoietin analogs, methods of production of the analogs, and compositions comprising the analog s.
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申请公布号 |
CA2345882(A1) |
申请公布日期 |
2000.05.04 |
申请号 |
CA19992345882 |
申请日期 |
1999.10.18 |
申请人 |
AMGEN INC. |
发明人 |
BROWN, JEFFREY K.;ELLIOTT, STEVEN G.;EGRIE, JOAN C. |
分类号 |
C12N15/09;A61K38/00;A61K38/18;A61K38/22;A61K47/10;A61K47/42;A61P7/06;C07K14/505;C12N1/15;C12N1/19;C12N5/10;C12N15/12;(IPC1-7):C12N15/18 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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