| 摘要 |
<p>coronary vasodilator compsn. comprising granules, not more than 2mm. in dia. of dipyridamole enclosed in a film, insoluble or only slightly soluble in water at 37 degrees C, which swells in contact with water and is degradable by man. The compsn. shows reduced side-effects such as headache, intestinal disorders and dizziness and also suppresses angina pectoris. Pref. film thickness is 0.1-200 mu m. When the interior of the granule comprises dipyridamol alone, it is to a concn. of 60-95%. It is pref. deposited on a biodegradable carrier such as starch, protein and esp. paraffins and stearin. Suitable film-formers are gelatin, ethylcellulose, polyvinyl alcohols, polyvinylpyrrolidone, polyamides etc. Pref. release time of the dipyridamol is 4-8 hr.</p> |
