PROCESS FOR PRODUCING 7-SQUARE BRACKET-BRACKETO 2-AMINOMETHYL-PHENYL-BRACKET CLOSED-ACETAMIDO-SQUARE BRACKET CLOSED-3-THIADIAZOLYL-THIOMETHYL-CEPH-3-EME-4-CARBOXYLIC ACID DERIVATIVES

摘要

7-(2-Aminomethylphenylacetamido-3-(heterocyclic-substituted)thiomethyl -3-cephem-4-carboxylic acids in which the heterocyclic substituent is 2-(1,3,4-thiadiazolyl)- or 2-(5-hydroxymethyl-1,3,4-thiadiazolyl)-, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.