发明名称 |
7-({60 -Sulfoacylamido)cephalosporins |
摘要 |
Novel cephalosporins of the formula, <IMAGE> wherein R is a hydrogen atom or an alkyl, aryl or thienyl group, and R' is a group which constitutes together with the adjacent nitrogen atom a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, which are effective particularly against Pseudomonas aeruginosa as well as against other Gram negative and positive microorganisms, for example, N-[7-( alpha -sulfophenylacetamido)ceph-3-em-3-ylmethyl] pyridinium 4-carboxylate, N-[7-( alpha -sulfo-3'-thienylacetamido)ceph-3-em-3-ylmethyl] pyridinium-4-carboxylate, and their pharmaceutically acceptable salts thereof. Sodium salt of the former is prepared by, e.g. reacting sodium 7-( alpha -sulfophenylacetamido) cephalosporanate with pyridine in water.
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申请公布号 |
US4065619(A) |
申请公布日期 |
1977.12.27 |
申请号 |
US19760719704 |
申请日期 |
1976.09.02 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
MORIMOTO, SHIRO;NOMURA, HIROAKI;FUGONO, TAKESHI;MINAMI, ISAO |
分类号 |
A61K31/545;C07D501/38;C07D501/44;C07D501/46;(IPC1-7):C07D501/44;A61K31/54 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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