发明名称 (2,3)-Epoxy-propoxy-phenyl-acrylic acid and acrylonitrile derivs. - intermediates for cardiac-active aryloxy-propanolamines
摘要 <p>New 1-phenoxy-2,3-epoxy-propane derivs. are of formula (I) (where R1, R1' are each H, 1-4c alkyl, 1-4C alkoxy, allyl, halo or nitro, and R2 is -CR3= CR4-COOR5 or -CR3=CR4-CN; R3 is H, 1-5C alkyl, aryl or aralkyl opt. substd. by lower alkyl or alkoxy gps.; R4 is H or 1-8C alkyl and R5 is H alkyl or aryl-lower alkyl). (I) are intermediates for 1-aryloxy-2-hydroxy-3-aminopropanes used for the treatment of cardiac disorders. Typical (I) is dl-3-(2-(2,3-oxidopropoxy)-phenyl)-crotononitrile.</p>
申请公布号 FR2352811(A1) 申请公布日期 1977.12.23
申请号 FR19770015887 申请日期 1977.05.25
申请人 HOECHST AG 发明人
分类号 A61K31/335;A61K31/336;A61P9/00;C07D303/20;C07D303/22;C07D303/24;C07D303/32;(IPC1-7):07D303/20 主分类号 A61K31/335
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