METHOD FOR THE PREPARATION OF DERIVATIVES OF SPIRO-(4,5)-DECANE AND DERIVATIVES THUS OBTAINED

摘要

1495647 1 - Oxa - 2 - oxo - 3,8 - diaza - spiro- 4,5-decane derivatives BUSKINE SA 11 Feb 1975 [12 Feb 1974] 5852/75 Heading C2C Compounds of Formula I wherein R is a benzyl, beta-phenyl-ethyl, 31 - 41 - methylendioxy - (beta - phenyl - ethyl), beta - (p - fluoro) - phenyl - ethyl, beta - phenoxy-ethyl, cinnamyl, diphenyl-methyl, beta- (31 - trifluoromethyl) - phenyl - ethyl group, and R1 is hydrogen or phenyl are prepared by reacting an N-R substituted piperid-4-one according to the Reformatykij modified method with a compound R1-CH(X)-COOC 2 H 5 where X is halogen to give a compound of Formula VI which is reacted with excess hydrazine to give a compound of Formula VII which is rearranged by the Curtins reaction to give compounds of Formula I above.