发明名称 |
Substituted piperidines therapeutic process and compositions |
摘要 |
The compounds are of the heterocyclic class of 2-phenethylpiperidines having an amido substituent in the ortho position of the phenethyl moiety. Substituents in the ortho position include formamido, benzamido, cinnamamido, 2-thiophenecarboxamido, alkanesulfonamido and alkanoylamido. They are useful as antiarrhythmic and/or antiserotonin agents. The novel compounds are prepared by reaction of appropriately substituted o-aminophenethylpiperidines and the carbonyl or sulfonyl halides or anhydrides. Typical embodiments of this invention are 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide and 2'-[2-(1-methyl-2-piperidyl)ethyl]cinnamanilide.
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申请公布号 |
US4064254(A) |
申请公布日期 |
1977.12.20 |
申请号 |
US19760734583 |
申请日期 |
1976.10.21 |
申请人 |
MEAD JOHNSON & COMPANY |
发明人 |
DYKSTRA, STANLEY J.;MINIELLI, JOSEPH L. |
分类号 |
C07D211/22;C07D211/26;C07D213/26;C07D213/30;C07D213/38;C07D213/40;C07D213/50;(IPC1-7):A61K31/44;A61K31/45 |
主分类号 |
C07D211/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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