Process for the preparation of trans-{66 {hu 9{b -isoambrettolide

摘要

A process is described for producing trans- DELTA 9-isoambrettolide from aleuritic acid in three reaction steps; first forming a dioxolane by treatment with an excess amount of an orthoformate or a dialkyl formamide dialkyl acetal; then forming the corresponding bengalene acid derivative by heating the dioxolane with acetic anhydride; and then cyclizing the resulting trans bengalene acid derivative by heating it, thereby yielding a high quality substantially pure or 100% pure trans- DELTA 9-isoambrettolide.