| 摘要 |
1373276 2 - Aryl - amino - imidazoline (2) compounds BOEHRINGER INGELHEIM GmbH 21 Jan 1972 [21 Jan 1971] 3031/72 Heading C2C Novel compounds of the Formula I wherein R 1 , R 2 and R 3 which may be the same or different and are hydrogen, fluorine, chlorine, bromine, methyl or ethyl and R 4 is and acid addition salts thereof may be prepared (a) by reaction of a compound II with R 4 CH 2 -Hal, where Hal is chlorine, bromine or iodine or (b) by reaction of a compound IV wherein A is cyano or -C(Y) : NH (in which Y is C 1-4 alkoxy or alkyl thio, amino or mercapto) with ethylene diamine or an acid addition salt thereof and optionally forming a salt of I. Pharmaceutical compositions of the compound I show analgesic activity and lower blood pressure when administered orally, parenterally, rectally or enterally with the usual excipients. |
