| 摘要 |
The present invention provides a vaccine composition comprising the B subunit of Shiga toxin or an immunologically functional equivalent thereof which is able to bind the Gb 3 receptor, complexed with an antigen, and further comprising an adjuvant, provided that when the adjuvant is solely a metal salt it is formulated in such a way that not more than about 50% of the antigen is adsorbed onto the metal salt. Such compositions provide an improved immune response compared to Shiga toxin or an immunologically functional equivalent thereof complexed with an antigen with no adjuvant, or an antigen alone with adjuvant.
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