发明名称 |
DERIVES DE PROSTAGLANDINES ET MEDICAMENTS CONTENANT CES DERIVES |
摘要 |
A compound of the formula I is prepared by oxidative treatment of a corresponding prostaglandin or prostaglandin-C1 to C4 ester with a halogenating agent. During this process, the 11 hydroxyl and 15 hydroxyl groups can be temporarily protected. By reducing the compounds, in which R denotes bromine or iodine, the corresponding compounds which are unsubstituted in the 5 position can be prepared. The compounds of the formula I, and their reduced derivatives, can be employed as drugs or as intermediates in chemical processes. <IMAGE>
|
申请公布号 |
FR2351113(A1) |
申请公布日期 |
1977.12.09 |
申请号 |
FR19770014202 |
申请日期 |
1977.05.10 |
申请人 |
WELLCOME FOUNDATION LTD |
发明人 |
SALVADOR MONCADA, NORMAN WHITTAKER ET HARRY TACON OPENSHAW;WHITTAKER NORMAN;OPENSHAW HARRY TACON |
分类号 |
C07D307/33;A61K31/34;A61K31/341;A61K31/343;A61K31/557;A61P7/02;A61P43/00;C07C405/00;C07D307/935;C07D307/937;(IPC1-7):C07D307/93;A61K31/36;C07C177/00 |
主分类号 |
C07D307/33 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|