摘要 |
<p>Quinazoline derivs. of formula (I) and their acid addn. salts are novel cpds. (where A is or -NR2-CnH2n-NR3 n=2,3 or 4; R2,R3 are each H or 1-4C alkyl and R is phenyl (opt. substd. by one or more gps. chosen from 1-4C alkyl, 1-4C alkoxy, and methylenedioxy), furyl thienyl or 5-alkylthio-1,3,4-oxadiazole-2-yl. (I) have marked antihypertensive activity of prolonged duration. The oral LD50 in mice is >500 mg/kg and i.p. LD50 in rats is generally >500 mg/kg. The cpds. do not affect cardiac rhythm and may be used to treat all types of hypertension by oral, rectal or parteral administration.</p> |